CROSS SECTIONAL STUDY TO CORRELATE CLINCOPATHOLOGIC FEATURES WITH PDL1, MSI A ND TIL IN 100 TRIPPLE NWGATIVE BREAST CANCER C ASES anjalisharma0406197@gmail.com

 

CROSS SECTIONAL STUDY TO CORRELATE CLINCOPATHOLOGIC FEATURES WITH PDL1, MSI A ND TIL IN 100 TRIPPLE NWGATIVE BREAST CANCER C ASES

1

India

Oral or Poster

Breast cancer is most common cancer in females throughout the world. TNBC has higher incidence and is aggressive disease , which contribute to higher mortality rate in India.

An observational cross sectional study was done on 100 TNBC operated cases. Clinicopathological features were correlated with IHC markers.

In present studymedian age of presentation was 50 years. Left breast was involved in 56% with involvement of UOQ. Poorly differentiated grade was observed in 73%. Lymphovascular invasion was seen in 54%. 59% of cases did not show Lymph node metastasis, 64 % belonged to T2 stage and 86% showed TILs ≤ 50 %. TILs response was significantly associated with T size, histological grade and PDL1 status. PDL1 marker was found positive in 35%, out of which 21% showed positivity in immune cell and 14% in tumor cells. There was significant association of PDL1 positivity with lymphovascular invasion. dMMR status was observed in 2 cases which showed negativity for nodal metastasis with TILs response less than equals to 50%, and one case was positive for PDL1 in tumor cells. There was no association seen between MSI and clinicopathological factors.

TNBC has unique clinicopathological and IHC features, determining its correlation with PDL1 , TIL and MSI can improve ability to predict prognosis and treatment response.