PREDICTIVE VALUE OF FNAC VERSUS ULTRASOUND TIRAD IN SOLITARY THYROID NODULE COMPARING WITH FINAL BIOPSY daniyal_zahoor2009@live.com

 

PREDICTIVE VALUE OF FNAC VERSUS ULTRASOUND TIRAD IN SOLITARY THYROID NODULE COMPARING WITH FINAL BIOPSY

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Pakistan

Oral or Poster

To find the predictive value of Fine Needle Aspiration Cytology versus Ultrasound TIRAD in solitary thyroid nodules keeping histopathology as the gold standard.

A prospective observational study was conducted at Department of general surgery, Jinnah postgraduate medical center, Karachi from Feburauary 2023 to December 2023 on 360 patients, representing diverse demographics. The mean age was 41.69±9.41 years, with a significant majority falling between 40 to 60 years (59.4%), predominantly females (68.9%). The study incorporated TIRADS scores based on radiological findings and Bethesda classification for cytopathology examination. Clinical, radiological, cytological, and histopathological features were analysed. The comparison between FNAC, TIRADS, and biopsy results was carried out, and diagnostic accuracy metrics were calculated.

TIRADS 4 (45.3%) and TIRADS 3 (30.3%) were the predominant categories in radiological findings. Bethesda 2 (60.3%) dominated cytopathology results. FNAC showed high sensitivity (98.51%) but lower specificity (27.17%), while TIRADS exhibited slightly better specificity (44.57%). The prevalence rates of benign cases were significantly higher for both FNAC and TIRADS. The association between biopsy results and cytopathology within different TIRADS categories was explored, revealing noteworthy patterns.

The study concludes that the association between FNAC versus ultrasound TIRAD in solitary thyroid nodules compared with final biopsy results emphasizes the importance of this combined diagnostic strategy for timely clinical decision-making. Precise identification of thyroid nodules will reduce unnecessary surgeries and will ensure timely intervention in thyroid malignancies.