EVALUATING TRANEXAMIC ACID IN BURN SURGERY: A SYST mahmoudalbashier934@gmail.com

 

EVALUATING TRANEXAMIC ACID IN BURN SURGERY: A SYST

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Egypt

Oral or Poster

Burn surgery is frequently complicated by profound intraoperative blood loss, increasing the need for transfusions and their associated complications. Tranexamic acid (TXA) has been shown to reduce surgical bleeding, but its use in burn surgery remains unclear due to conflicting evidence. This systematic review and meta-analysis aim to determine the efficacy and safety of tranexamic acid in reducing intraoperative blood loss, transfusion requirements, and postoperative complications in adults undergoing acute burn surgery compared to a placebo.

We conducted a systematic search in PubMed, Scopus, Cochrane, Embase, and Web of Science up to March 8, 2025, based on PRISMA guidelines. Data extraction and risk-of-bias assessment were conducted independently. We conducted a meta-analysis using (RevMan) 5.4, with heterogeneity assessed by chi-square and I² statistics and a random-effects model as needed.

Six studies, consisting of four RCTs and two cohort studies involving 427 patients, were included. TXA effectively lowered the overall blood loss (MD = -165.01 mL, 95% CI: -210.13 to -119.89, p < 0.00001, I² = 55%) and the ratio of blood loss compared to total body surface area (MD = -5.90, 95% CI: -8.17 to -3.63, p < 0.00001, I² = 40). We resolved the heterogeneity by conducting a sensitivity analysis in some outcomes, and the risk of bias was low to moderate.

This meta-analysis supports the use of tranexamic acid in burn surgery to reduce total blood loss and transfusion requirements without increasing thromboembolic events or mortality.