ASSOCIATION OF OBESITY WITH COMPLICATIONS OF ACUTE PANCREATITIS daniyal_zahoor2009@live.com

 

ASSOCIATION OF OBESITY WITH COMPLICATIONS OF ACUTE PANCREATITIS

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Pakistan

Oral only

To determine the association between obesity and complications of acute pancreatitis including mortality, pancreatic necrosis and organ failure.

Study design Cohort study. Place & Duration of study This prospective study was done in the Department of General Surgery, Jinnah Postgraduate Medical Center (JPMC) Karachi, from February 2024 to June 2024. Methods The study included 184 patients with acute pancreatitis. Patients were divided into obese and non-obese categories based on their BMI. There were 92 obese individuals with body mass index (BMI) > 30 kg/m² and 92 individuals who were non-obese. Clinical, physiological, and biochemical data were collected and analyzed to assess any statistically significant association.

The mean age of the patients was 54.33±11.22 years and 54.24±13.20 years for obese and non-obese groups. Majority (n=99-53.8%) of our patients had moderate category of pancreatitis. The in-hospital mortality rate among obese patients diagnosed with acute pancreatitis was higher (n=14 - 15.2%) as compared to non-obese patients (n=3 - 3.3%). Moreover, in comparison to non-obese patients, pancreatic necrosis and organ failure were more frequently observed in obese patients (n=17 - 18.5%) and (n=44 - 47.8%) respectively. The relative risk of mortality and organ failure were significantly elevated among obese individuals than non obese patients (RR=1.763 and 1.601, respectively).

Obesity significantly correlates with worse outcomes in patients with acute pancreatitis, including higher mortality and organ failure rates. This highlights the importance of BMI as a significant predictor of complications