GASTROINTESTINAL STROMAL TUMORS WITH ATYPICAL FEATURES AND PRESENTATIONS: A CASE STUDY mekashawaltaseb2@gmail.com

 

GASTROINTESTINAL STROMAL TUMORS WITH ATYPICAL FEATURES AND PRESENTATIONS: A CASE STUDY

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Ethiopia

Oral or Poster

Gastrointestinal stromal tumours (GISTs) are the most common non-epithelial gastric neoplasms and the most frequent mesenchymal tumours that affect the digestive tract. Although the majority of GISTs occur in the stomach (60–70%), they can arise anywhere along the GI tract as well as in extra visceral locations. Most cases are asymptomatic and often detected incidentally during imaging. Surgery is typically used to treat localized GISTs. Imatinib is the adjuvant treatment for patients who have a high risk of recurrence after primary GISTs have been removed. Here we present the atypical presentations (clinical and histomorphologic) and management of four cases of GISTs.

The cases were operated at three centres in the Sidama regional state, Ethiopia. The first two cases were a 35-year-old female and 72-year-old male patient diagnosed to have an acute abdomen and underwent exploratory laparotomy, histomorphologic diagnosis confirmed to be an extra-GI mesenteric and a jejunal GIST respectively. The third case was a 65-year-old male patient diagnosed withgastro-gastric intussusception and underwent partial gastrectomy. The histomorphology was confirmed to be gastric GIST. The fourth case was a 45-year-old male patient who underwent exploratory laparotomy with a diagnosis of gastric mass with liver secondaries. He underwent wedge gastrectomy. The histomorphologic diagnosis turned out to be high-grade gastric GIST.

All the cases had a favorable postoperative outcome and discharge improved.

GISTs can have atypical presentation and histologic features. Surgery is the standard treatment. A thorough histologic examination is crucial for adjuvant treatment and prognostication.