THE NUMBER OF RESECTED LYMPH NODES FROM THE UPPER MEDIASTINAL AREA PREDICTS LONG-TERM OUTCOMES OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA AFTER ESOPHAGECTOMY FOLLOWING NEOADJUVANT CHEMOTHERAPY

Slot ID

PW03-13

Abstract Title

Author Details

No. of Authors

8

Including the presenting author

Author 1

Sean Michael Stanat seanstanat1711@gmail.com Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan *

Author 2

Yasufumi Koterazawa kote1128@med.kobe-u.ac.jp Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan

Author 3

Hironobu Goto hirogoto@med.kobe-u.ac.jp Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan

Author 4

Naoki Urakawa urakawa@med.kobe-u.ac.jp Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan

Author 5

Hiroshi Hasegawa hasega@med.kobe-u.ac.jp Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan

Author 6

Shingo Kanaji kanashin@med.kobe-u.ac.jp Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan

Author 7

Takeru Matsuda tmatsuda@med.kobe-u.ac.jp Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan

Author 8

Yoshihiro Kakeji kakeji@med.kobe-u.ac.jp Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery, Department of Surgery Kobe Japan

Author 9

Author 10

Author 11

Author 12

Presenting Author Name

Sean Michael Stanat

Presenting Author Email

seanstanat1711@gmail.com

Presenting Author Country

Japan

Abstract

Abstract type

Oral or Poster

Introduction *

The total number of resected lymph nodes (LNs) is an important determinant of longer survival after esophagectomy for esophageal squamous cell carcinoma (ESCC). However, resected LN counts from which areas affect long-term outcomes remain unclear.

Material & Method *

This study comprised 406 patients who underwent esophagectomy at Kobe University Hospital. Resected LN counts were evaluated in the following areas: upper mediastinal (UM), middle mediastinal, lower mediastinal, and abdominal. Cut-off values for LN counts from each area were determined using receiver operating characteristics analysis to the survival status. Cox proportional hazards regression analyses were performed to identify prognostic factors.

Results *

The cut-off values for large or small numbers of resected LN counts in the UM, middle mediastinal, lower mediastinal, and abdominal areas were 4, 8, 5, and 22, respectively. Multivariate analysis in patients with upper and middle thoracic (Ut/Mt) ESCC revealed that the resected LN count from the UM area was an independent risk factor for overall survival. In patients with lower thoracic ESCC, resected LN counts from no areas were prognostic factors. In patients with Ut/Mt ESCC after neoadjuvant chemotherapy, the resected LN count from the UM area was an independent risk factor for overall survival.

Conclusion *

The number of resected LNs from the UM area influenced survival outcomes of patients with Ut/Mt ESCC after esophagectomy following neoadjuvant chemotherapy.

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International Society of Surgery (ISS)

Société Internationale de Chirurgie (SIC)

THE NUMBER OF RESECTED LYMPH NODES FROM THE UPPER MEDIASTINAL AREA PREDICTS LONG-TERM OUTCOMES OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA AFTER ESOPHAGECTOMY FOLLOWING NEOADJUVANT CHEMOTHERAPY seanstanat1711@gmail.com