ADJUVANT OSTEOGENETIC INDUCERS IN CHEST WALL RECONSTRUCTION cristiangar789@gmail.com

PE106

ADJUVANT OSTEOGENETIC INDUCERS IN CHEST WALL RECONSTRUCTION

5

 

 

 

 

Mexico

Oral or Poster

Thoracic trauma mortality rate of 10-25%. 15-25% require surgery. firearms-related trauma accounts for 10-20%.Tissue engineering, especially in bone matrix, is used as a natural osteoinductive scaffold. It replaces or repairs bone tissue to create scaffolds that mimic natural tissue, promoting regeneration, especially in complex fractures, using mesenchymal stem cells.

28-year-old male with a history of penetrating chest trauma caused by a firearm (shotgun), with multiple rib fractures, loss of chest wall integrity, lung laceration, and diaphragmatic laceration. Flexible fixation osteosynthesis material was used using the truss rod technique for rib wall reconstruction, and demineralized bone matrix (DBM) seeded with osteogenically induced bone marrow stromal cells (BMSC) was used as an adjuvant to reconstruct the chest wall defect.

The truss rod technique improves respiratory physiology and increases functional capacity by fixing the posterior costal surface and maintaining mobility of the anterior surface without interfering with the amplexing and amplexing movements of the chest wall. This technique reduces pain by reducing tension.

DBM is cadaveric bone tissue without minerals, only protein components: calcium, inorganic phosphates, and cellular debris with osteogenic and osteoinductive properties (providing bone morphogenetic proteins). It induces the differentiation of stem cells into osteoblasts, inducing new bone formation through the endogenous release of these compounds to bone wound sites where it is surgically placed to fill bone defects.