BIOLOGICAL BIOMARKERS IN ACUTE APPENDICITIS IN ADULTS danielbarocio03@gmail.com

PE060

BIOLOGICAL BIOMARKERS IN ACUTE APPENDICITIS IN ADULTS

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Mexico

Poster Exhibition only

Acute appendicitis (AA) is one of the most common surgical emergencies in clinical practice. In children, some biological biomarkers (BB) such as lymphocyte/monocyte ratio (LMR), neutrophil/lymphocyte ratio (NLR), as well as platelet/lymphocyte ratio (PLR) have been proposed for diagnosis of AA (Arredondo - Montero Surg Infect 2023). AA on adults (AAA) and BB have not been reported yet.

To report a retrospective cohort of BB such as LMR, NLR, PLR and C-reactive protein in AAA study design was retrospective (from January 2024 to May 2025). We included 69 adult patients who underwent surgery for suspected AA and were diagnosed with AA based on the pathology report. It is important to note that They were divided into three groups: non-appendicitis, phase 1/2 and phase 3/4 inflammatory (table 1). All those with CBC count, CRP, liver function tests and pathology report were included primarily.

11 cases (16%) were non-appendicitis, 34 in phase 1/2 (uncomplicated, 49%) and 23 in phase 3/4 (Complicated, 33.3%). Table 2 shows the characteristics and differences between the three groups. Age, LMR and CRP were statistically different (p<0.05). NLR, total bilirubin and serum albumin showed a trend. More days at hospital were observed in advanced phases of AA. CRP showed Sen77.8%, Spec100%, PPV100%, NPV33.3% with Area Under Curve 0.85 (p<0.001, Figure 1)

High CRP, older patients and low LMR were associated with complicate AAA. CRP is excellent BB at identifying people who do not have AA (low NPV).