REDUCTION OF COMPLICATIONS IN SURGICAL PATIENTS THROUGH NEBULIZED DRUGS cristiangar789@gmail.com

295-05

REDUCTION OF COMPLICATIONS IN SURGICAL PATIENTS THROUGH NEBULIZED DRUGS

4

Mexico

Oral or Poster

Synergistic effect of budesonide, salbutamol, and ipratropium bromide on lung function, inflammatory response to lung surgery, Evaluated through cytokine measurements in BLF; reduced concentrations of TNF-α, IL 1β, IL 6, and IL 8 in BLF.

159 patients scheduled for major lung resection segmentectomy, lobectomy, and wedge resection, with a distribution of 79 men and 80 women age range 18 to 85 years Dx NPS, Lung disease under study, lung metastasis, miliary disease, postinfectious necrosis, granulomatous disease, adenocarcinoma lung cancer, bullous disease, lung sequestration, mesothelioma All managed with nebulizations initiated in the immediate postoperative period with budesonide 0.250mcgr every 12hr, salbutamol 2.5 mg + ipratropium bromide 0.5 every 8hr undiluted, early mobilization, early passive pulmonary rehabilitation exercises, pain management with goals based on the analogous pain scale

All patients nebulized with schedule from the 2nd hour after surgery, using inhaled steroids and local bronchodilator based on anticholinergic and B2 adrenergic, Improvement was found in oxygen saturation maintaining figures equal to or greater than 90% with weaning of the same at 24hr postoperatively, improvement in expectoration along with bronchial clearance and exercise tolerance after nebulization

Nebulization of budesonide improves ventilatory mechanics and reduces the inflammatory response; salbutamol treatment induced significant increases in Pao2/Fio2 ratio accelerates the resolution of lung edema, improves blood oxygenation, and stimulates cardiovascular function. The synergistic reduce extravascular lung water improves oxygenation by stimulating epithelial fluid clearance and cardiovascular function