A RANDOMIZED CONTROL CLINICAL TRIAL TO STUDY THE ROLE OF PRE- OPERATIVE CARBOHYDRATE LOADING IN MAJOR ABDOMINAL SURGERIES sejalgrover98@gmail.com

342-05

A RANDOMIZED CONTROL CLINICAL TRIAL TO STUDY THE ROLE OF PRE- OPERATIVE CARBOHYDRATE LOADING IN MAJOR ABDOMINAL SURGERIES

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India

Oral or Poster

It has been reported that preoperative consumption of carbohydrate-rich liquid diet reduces patient discomfort and anxiety in the perioperative period, and resulted in a shorter hospital stay. Preoperative carbohydrate loading is a contemporary element of the enhanced recovery after surgery (ERAS) paradigm. In addition to intraoperative surgical and anesthetic modifications and postoperative care practices, preoperative optimization is essential to good postsurgical outcomes. The aim of this article is to review pre-operative carbohydrate loading that may help reduce catabolism, maintain immune function and improve recovery with particular focus on carbohydrate loading and immunonutrition.

Intake of 100 g of carbohydrate (800 mL of CHOD) in the evening before surgery, and 50 g of carbohydrate (400 mL of CHOD) until 2 hours before surgery [ERAS recommendation]. They were asked to consume CRLD prior to surgery as specified above. Blood samples were collected prior to and post the surgery to compare the insulin and glucose levels

There were no postoperative complications. Sixty percent of the controls and 22% of the CHO group experienced at least one episode of vomiting. Biochemical analysis showed that serum glucose (P < 0.01), insulin (P < 0.01), lactate/pyruvate ratio (P = 0.03), and triglycerides (P < 0.01) for the control group were higher than for the CHO group. The value of HOMA-IR was significantly greater (P = 0.027) in the conventionally fasted patients than in the CHO group.

Preoperative carbohydrate loading seems to put the patient in a better metabolic state and catabolism responses are less pronounced in patients.