ADIPOSE-DERIVED STROMAL CELLS FOR WOUND REPAIR maryana.teufelsbauer@meduniwien.ac.at

 

ADIPOSE-DERIVED STROMAL CELLS FOR WOUND REPAIR

2

Austria

Oral only

Mesenchymal stromal cells (MSCs) hold great perspective for the therapy of a host of diseases due to regenerative and anti-inflammatory properties by differentiation into diverse cell populations, homing to damaged tissue regions, paracrine effects and release of extracellular vesicles. MSCs and Adipose-derived stromal cells (ADSCs) expressing typical markers can be isolated from bone marrow or white fat tissue in considerable numbers and applied for benign and malignant diseases. The MSCs may be administered as whole cells or in form of their secretome that is held responsible for most of their beneficial effects.

In a pilot study, ADSCs were recovered from fat aspirations of two diabetic patients with large wounds that proved inaccessible to therapy and resulted in uncovered tissue.

The single application of several millions of ADSCs to the borders of the wounds resulted in limited wound coverage but was not enough to provide healing of the defects. ADSCs expanded in tissue culture were administered repeatedly for several months and complete coverage of the lesions with newly-built tissue could be achieved.

The applications of MSCs and ADSCs are amply documented and have been investigated in preclinical models and a few controlled trials. Larger numbers of MSCs and ADSCs can be obtained for allogeneic transfer but imply difficulties. In conclusion, isolation, expansion and clinical administration of ADSCs/MSCs hold great potential for the therapy of difficult-to-treat wound lesions.