DOEGE–POTTER SYNDROME SECONDARY TO AN IGF2-PRODUCING SOLITARY FIBROUS TUMOR WITH MEDIASTINAL AND ABDOMINAL RECURRENCE: A CASE REPORT alinebiersacksixx@gmail.com

PE036

DOEGE–POTTER SYNDROME SECONDARY TO AN IGF2-PRODUCING SOLITARY FIBROUS TUMOR WITH MEDIASTINAL AND ABDOMINAL RECURRENCE: A CASE REPORT

7

Mexico

Oral or Poster

Doege–Potter syndrome (DPS) is a rare paraneoplastic manifestation characterized by hypoglycemia secondary to tumor production of insulin-like growth factor type 2 (IGF2), most commonly associated with solitary fibrous tumors (SFTs). Its recognition is important due to the potential for late recurrence and multifocal disease.

We present a case report structured according to the CARE (CAse REport) guidelines of a 68-year-old male with a history of hepatic IGF2-producing SFT resected in 2018, managed at the Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubirán.” Clinical, imaging, surgical, and histopathological data were extracted from institutional electronic medical records. Diagnosis and therapeutic decisions were determined through multidisciplinary consensus.

A 68-year-old male, after seven years of clinical remission, presented with multifocal recurrence documented by computed tomography, involving lesions in the anterior mediastinum and abdominal cavity. Biopsy confirmed recurrent SFT with positive expression of STAT6, CD34, and CD99, and a Ki-67 index of 10%. The surgical approach included mediastinal resection assisted by video-assisted thoracoscopic surgery (VATS) with indocyanine green localization, achieving negative margins without postoperative complications. The patient remains under multidisciplinary surveillance, with planned resection of the abdominal lesions and no new episodes of hypoglycemia.

DPS secondary to SFT poses diagnostic and therapeutic challenges due to its rarity, risk of late recurrence, and potential multifocality. Optimal management requires histopathological and immunohistochemical confirmation, complete surgical resection, and long-term follow-up in specialized centers.