DOES AGE IMPACT BREAST CANCER OUTCOMES IN INDIAN WOMEN? RESULTS FROM A 5-YEAR COHORT STUDY FROM NORTH INDIA endosurgeonrinellem@gmail.com

PW04-12

DOES AGE IMPACT BREAST CANCER OUTCOMES IN INDIAN WOMEN? RESULTS FROM A 5-YEAR COHORT STUDY FROM NORTH INDIA

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India

Oral or Poster

Age at diagnosis potentially influences prognosis of breast cancer (BC). Whether survival–age relationship is linear across age-groups remains unclear. We evaluated effect of age on BC outcomes in Indian women and identified outcome-related factors.

Consecutive primary BC patients managed using standard age-appropriate protocols per disease stage, biology at a north Indian tertiary-care institute during 2017-2021 with minimum 1-year follow-up. Patients were categorized into: Group-A- Young, <40 years(y); Group-B- 41-69y; Group-C- Elderly>70 y. Analyses of associations between age and overall survival (OS), disease free survival (DFS) and breast cancer specific death (BCSD) in months were done using appropriate statistical methods. Influence of histology, grade, stage and hormone-receptor status were evaluated in stratified analyses.

Mean(+S.D.) age at diagnosis of 737 patients was 49.9±11.9y. Group-C had the worst OS, though insignificant(HR 1.81; 95%CI, 0.79–4.16; p=0.16)* and experienced 10-month shorter DFS- 68.3 months(HR,2.93; 95%CI, 1.06–8.09; p=0.03). Groups-A and -B had similar DFS(HR,1.16; 95%CI, 0.54–2.48; p=0.79)*. BCSD was similar across all age-groups(Group-B- HR,0.75; 95%CI, 0.44–1.28; p=0.29, Group-C- HR,0.89; 95%CI, 0.30–2.66; p=0.85)*. Comparison of outcomes, and factors influencing outcomes in three groups is provided in Figure-1. Stratified analyses showed that elderly women, infiltrating lobular carcinoma, bilateral and stage III/IV disease faced poorer prognoses. * reference- young age group

More younger BC patients presented with advanced disease. When stratified for stage and tumor-biology, elderly women experienced shorter OS and DFS, similar BCSD. Age of diagnosis by itself didn’t influence BC outcomes, independent of disease stage and biology.